Our results suggest that exosomal miR-92a-3p regulates cartilage development and homeostasis by directly targeting WNT5A. This indicates that exosomal miR-92a-3p may act as a Wnt inhibitor and exhibits potential as a disease-modifying osteoarthritis drug.

Fem miRNA (miR-16, miR-25, miR-92a, miR-451 och miR-486-5p) visade konsekvent förhöjda nivåer i plasma hos GC-patienterna jämfört med kontroller och 

IDs. MGI:3629918. NCBI Gene: 751549. Member of. 28 Aug 2020 MicroRNAs (miRNAs) refers to a small, short non-coding RNA of endogenous class. They have shown to h.

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In colorectal cancer, KLF4 has been reported to Methods: Exosomal miR-92a-3p expression was assessed in vitro in a human mesenchymal stem cell (MSC) model of chondrogenesis and in normal and OA primary human chondrocytes (PHCs). MSCs and PHCs were treated with exosomes derived from MSC-miR-92a-3p (MSC-miR-92a-3p-Exos) or its antisense inhibitor (MSC-anti-miR-92a-3p-Exos), respectively. 2011-05-13 2021-02-20 Previous study demonstrated that Mesenchymal stem cells secretes a variety of growth factors, cytokines, and miRNAs (including miRNA-92a) both free and in exosomes. Women with PCOS showed downregulation of miRNA-92a and high gene expression of main androgen-producing steroidogenic pathway genes CYP17A1, CYP11A1 and DENND1A in ovarian theca cells. MiRNA expression in tumor samples. Boxplot showing the relative expression distribution of miR-21, miR-31, miR-92a, miR-101, miR-106a and miR-145. qRT-PCR was performed and Ct values for each miRNA was normalized against RNU44 and the relative expression was calculated using 2-dCt method.

26 okt. 2017 — MikroRNA (Mirna) är vävnad specifika, små, icke-kodande RNAs har-miR-​451a, har-miR-486-5 p, har-miR-660-5 p och har-miR-92a - 3p.

Down‐regulated miRNA, miR‐92a‐1‐5p, was overexpressed in BeWo cells followed by forskolin treatment to understand its relevance in the process of BeWo cell fusion by desmoplakin I+II staining and hCG secretion by ELISA. MiRNA-92a overexpression was associated with improve overall survival. It could be explained through deregulation of target genes or geographic patterns of miRNA expression. Conclusion: MiRNA-133a was underexpressed in study group, and over expression of miRNA-92a was associated with better overall survival 2020-03-30 · Background miR-92a-3p and oxidative stress are reportedly associated with venous thrombosis.

Expression level of miR-92a was detected by the TCGA database and was confirmed by non-small-cell lung cancer (NSCLC) tissues. Targets of miR-92a were predicted using starbase, and validated by dual luciferase assay.

First, miR-92a ex-pression was higher in HUVECs exposed to atheroprone low Original Article The Different Roles of miRNA-92a-2-5p and let-7b-5p in Mitochondrial Translation in db/db Mice Huaping Li, 1,2Beibei Dai, Jiahui Fan, 1,2 Chen Chen, Xiang Nie, Zhongwei Yin, Yanru Zhao, Xudong Zhang, and Dao Wen Wang1 1Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Key 2015-01-27 In the present study, we found that the upregulation of miRNA-92a-3p induced by TBI correlated with a decrease in integrin binding sialoprotein (IBSP) expression in callus formation. In vitro, overexpressing miRNA-92a-3p inhibited IBSP expression and accelerated osteoblast differentiation, whereas silencing of miRNA-92a-3p inhibited osteoblast activity. MicroRNA (miR)-17-92a expression plays a crucial role in lymphocyte ontogeny. We therefore set out to determine miR-92a expression levels in peripheral blood lymphocytes from healthy subjects to ascertain any association between these levels and ageing.

This pre miRNA sequence is 78 nucleotides long and is found in Homo sapiens. Annotated by 9 databases (RefSeq, GeneCards, HGNC, Ensembl/GENCODE, MalaCards, Rfam, miRBase, Ensembl, ENA).
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Product filter. miR-92a-3p. 2021-02-15 2012-06-01 MiRNA-92a promotes cell proliferation and invasion through binding to KLF4 in glioma. Role of MiRNA-92a in glioma 6613 S transition of the cell cycle following DNA dam - age by mediating the tumor suppressor gene p53 15.

To investigate the role of miRNA-92a in HG conditions, caspase3 activity was measured to assess the apoptosis effect.
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Changes in miRNA(s) profile of BeWo cells treated with forskolin were analyzed using Affymetrix miRNA microarray platform. Down‐regulated miRNA, miR‐92a‐1‐5p, was overexpressed in BeWo cells followed by forskolin treatment to understand its relevance in the process of BeWo cell fusion by desmoplakin I+II staining and hCG secretion by ELISA.

MiRNA-92a promotes cell proliferation and invasion through binding to KLF4 in glioma. Liu PJ(1), Ye YX, Wang YX, Du JX, Pan YH, Fang XB. Author information: (1)Department of Oncological Radiotherapy, the Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China. oie464266@163.com. Each single miRNA of miR-92a family also yielded high diagnostic effectiveness with AUC of 0.90 [0.87–0.93] for miR-25, 0.94 [0.92–0.96] for miR-92a and 0.89 [0.82–0.95] for miR-363.